Humanitarian groups said the conflict has forced them to reroute shipments through longer and more expensive pathways, with transport costs rising sharply due to increased fuel prices and insurance premiums.

The disruption has compounded existing financial strain following reductions in U.S. foreign aid.The World Food Programme said tens of thousands of metric tons of food are currently delayed in transit.

The International Rescue Committee reported that pharmaceuticals intended for Sudan are stranded in Dubai, while hundreds of boxes of therapeutic food meant for malnourished children in Somalia remain stuck in India.

The United Nations Population Fund said it has also delayed shipments of medical equipment to 16 countries, underscoring the scale of the disruption.The United Nations described the situation as the most significant supply chain shock since the COVID-19 pandemic, with costs increasing by up to 20% as shipments are rerouted and delayed.

Aid agencies are increasingly relying on a combination of land, air and sea transport to bypass affected routes. UNICEF said it has shifted vaccine deliveries to Iran via Turkiye by air and road, adding about 10 days to delivery times and increasing costs by roughly 20%.

Save the Children said it has altered supply routes to Sudan, including overland transport through Saudi Arabia and barge crossings of the Red Sea, increasing delivery times by about 10 days and costs by approximately 25%.

The delays risk disrupting supplies to more than 90 primary health care facilities in Sudan.The Doctors Without Borders said rising fuel prices in Somalia have increased transport and food costs, limiting access to care for populations already facing severe food insecurity.Aid groups warned that the impact on global hunger could worsen significantly.

The World Food Programme said that if the conflict continues through June, an additional 45 million people could face acute hunger, adding to nearly 320 million already affected worldwide.The disruption also threatens agricultural production, with around 30% of global fertilizer supplies passing through the Strait of Hormuz.

Countries such as Sudan and Kenya rely heavily on imports from the Gulf, raising concerns about planting seasons in regions including East Africa and South Asia.

The United Nations said it has established a task force to facilitate fertilizer trade, but aid agencies cautioned that without a ceasefire and increased funding, humanitarian operations may struggle to meet rising needs.

The United States said it remains a leading contributor to global humanitarian assistance and announced an additional $50 million in emergency aid to Lebanon, including support for the World Food Programme, as it works with international partners to address the growing crisis.