The Afghan Taliban government said the strike, which hit a facility in the capital late on Monday as patients and staff were praying ahead of the end of Ramadan, also wounded at least 265 people.

The casualty figures have not been independently verified.The United Nations Assistance Mission in Afghanistan (UNAMA) told Reuters that 143 people were killed and 119 wounded, offering a significantly lower toll than Afghan authorities.

Relatives gathered at the site on Wednesday, combing through lists and debris in search of loved ones who had been undergoing treatment at the centre.

“We came here looking for our patient, he is missing,” said Mazar, 50, who gave only one name.

“We checked the lists, but his name was not in the list of the living. Maybe he is injured or has been killed.”Afghanistan’s interior ministry said funerals for some of those killed would take place later in the day.

Afghan authorities said the strike hit a well-known civilian rehabilitation centre, formerly a NATO military base known as Camp Phoenix that had been converted into a treatment facility about a decade ago.

Pakistan rejected those claims, stating that its forces had “precisely targeted military installations and terrorist support infrastructure,” disputing assertions that civilians were the primary victims.

Independent experts said verifying the exact nature of the target would be difficult without a third-party investigation, given sharply conflicting accounts from both sides.

The strike marks a sharp deterioration in relations between Afghanistan and Pakistan, already strained by cross-border security concerns. The incident comes amid broader regional instability linked to the ongoing U.S.-Israeli conflict with Iran, further complicating the security landscape.

Katz said in a statement that the operation targeted Khatib as part of Israel’s ongoing military actions against senior Iranian officials. He added that he and Netanyahu had granted the military authority to eliminate additional high-ranking Iranian figures without requiring further approval.

Iranian officials have not publicly confirmed Khatib’s death, and there has been no immediate response from Tehran regarding the Israeli claim. The absence of verification leaves the status of the Iranian intelligence chief unclear.

Katz’s remarks indicate a potential broadening of Israel’s operational mandate, suggesting a shift toward faster decision-making in targeting senior adversaries. The authorization to proceed without additional political clearance points to heightened tensions and a more aggressive posture.

Regional implicationsThe reported strike, if confirmed, could mark a significant escalation in the confrontation between Israel and Iran, particularly given the seniority of the alleged target. Developments are likely to be closely monitored for their impact on regional stability and the risk of further retaliatory actions.

Israel said the missiles dispersed multiple submunitions mid-air, complicating interception efforts. The overnight attack killed two people in Tel Aviv, bringing the total death toll in Israel since the start of the war to at least 14, according to Israeli authorities.

Iran described the strike as a direct response to the assassination of Larijani, one of the most senior figures killed since the conflict began more than two weeks ago. Tehran confirmed his death on Tuesday, following earlier Israeli statements that he had been targeted in an airstrike.

Iran’s Supreme National Security Council, which Larijani had previously headed as secretary, said his son and deputy, Alireza Bayat, were also killed in a separate Israeli attack on Monday night.

In a separate development, Iran said a projectile struck near the Bushehr Nuclear Power Plant on Tuesday evening but caused no damage or injuries. The country informed the International Atomic Energy Agency of the incident.

IAEA Director General Rafael Grossi renewed calls for maximum restraint, warning of the risk of a nuclear accident if strikes continue near sensitive facilities.

The United States and Israel have said their campaign aims in part to prevent Iran from developing a nuclear weapons programme. The strikes have killed multiple senior Iranian officials, including Supreme Leader Ali Khamenei in the opening phase of the conflict.

Iran’s newly appointed supreme leader Mojtaba Khamenei has rejected proposals to de-escalate, according to a senior Iranian official. Speaking at his first foreign policy meeting since taking office, he said it was not the right time for peace and that Iran would continue its confrontation until its adversaries accepted defeat and paid compensation.

The exchange of strikes underscores the intensifying trajectory of the conflict, with both sides expanding targets and rhetoric while international agencies warn of broader regional and nuclear risks.

Iran’s semi-official Fars news agency reported that Larijani, 67, died in the strike, while Israel’s Defence Minister Israel Katz said earlier that he had been targeted and killed in an Israeli operation. There was no immediate independent confirmation of the circumstances of the attack.

Larijani, a prominent figure from a clerical family that rose to influence after the 1979 Islamic Revolution, held a series of senior roles across Iran’s political and security establishment.

A former commander in the Revolutionary Guard during the Iran-Iraq war, he later led the state broadcaster and served as secretary of the Supreme National Security Council.

He was also speaker of parliament for 12 years, consolidating his position as a key intermediary between Iran’s political factions and the office of the supreme leader.

As one of Khamenei’s trusted lieutenants, Larijani played a central role in shaping Iran’s nuclear strategy, which sought to advance atomic capabilities while avoiding direct confrontation with Western powers. He was a frequent interlocutor in negotiations, presenting Iran’s position in public and diplomatic settings.

His portfolio extended beyond nuclear policy to include managing regional alliances and overseeing internal security responses during periods of unrest.

Despite being viewed by some analysts as relatively pragmatic compared to other hardline figures, Larijani was accused by Western officials of involvement in the suppression of anti-government protests earlier this year. The crackdown, which resulted in thousands of deaths, led Washington to impose sanctions on him last month.

Following the launch of U.S.-Israeli strikes on Feb. 28, Larijani publicly accused Iran’s adversaries of attempting to destabilize and weaken the country, while warning against domestic dissent.

His death comes amid intensifying military exchanges that have targeted senior Iranian figures, raising questions about the resilience of Tehran’s leadership structure and the future direction of its security and nuclear policies.

“In a precise strike in Tehran: The IDF eliminated the Commander of the Basij Unit,” the Israeli military said in a statement, adding that Soleimani had led the Basij for the past six years.

It said the operation was carried out by the Israeli Air Force based on intelligence.Israeli media reported that Larijani, a senior figure in Iran’s political and security establishment, was also targeted for assassination, though no confirmation on his status was immediately available.

The Basij is a volunteer paramilitary force operating under Iran’s Islamic Revolutionary Guard Corps and has played a central role in enforcing internal security.

Israel’s military said the Basij had led “main repression operations” during recent mass protests in Iran, which it cited as part of the rationale for the strike.

Iran experienced widespread unrest that peaked in January, with demonstrations challenging the clerical establishment. According to rights groups, the crackdown that followed resulted in thousands of deaths and tens of thousands of arrests.

The Israeli military said the strikes were part of broader operations that yielded “significant preventive achievements overnight,” quoting Chief of Staff Lieutenant General Eyal Zamir.

The targeting of senior Iranian figures in Tehran, if confirmed, would mark a notable escalation in Israel’s operations, extending beyond regional proxy engagements into direct action within Iran’s capital.

There was no immediate response from Iranian authorities regarding the reported strikes or casualties.

The statement marks a further escalation in the ongoing conflict between Israel and Iran, where both sides have intensified military operations targeting senior leadership figures.

Conflicting accounts emergeWhile Israeli officials declared Larijani dead, earlier reports citing Israeli sources indicated that his fate remained unclear following strikes that targeted him, leaving uncertainty over whether he had been killed or wounded.

Iran has not issued any official response confirming his death.Key figure in Iran’s power structureLarijani, a senior political and security figure, has played a central role in Iran’s leadership apparatus, particularly after the reported killing of Supreme Leader Ayatollah Ali Khamenei in earlier U.S.-Israeli strikes that reshaped the country’s command structure.

His removal, if confirmed, would represent one of the most significant blows to Iran’s leadership since the start of the current conflict.

The reported strike comes amid a wider Israeli campaign targeting Iran’s military and security elite. Israeli operations have also reportedly killed other senior figures, including commanders linked to the Basij militia, a key internal security force.

The targeting of high-ranking officials signals a strategy aimed at weakening Iran’s command-and-control capabilities as hostilities continue to expand across the region.

The developments underscore the widening scope of the conflict, which has already drawn in multiple regional actors and disrupted energy markets and security dynamics across the Middle East.

With no confirmation from Tehran and conflicting accounts still emerging, the situation remains fluid.

The Taliban said at least 400 people were killed and 250 injured in the strike, which it said hit a drug rehabilitation hospital, while Pakistan rejected the claim, saying it targeted military installations and “terrorist support infrastructure.

Pakistan had long been a key backer of the Taliban, supporting its emergence in the 1990s as part of a broader strategy to secure “strategic depth” in its rivalry with India.

Relations initially appeared strong after the Taliban returned to power in 2021, with then-prime minister Imran Khan welcoming the development. However, ties deteriorated as Islamabad accused Kabul of failing to curb militant groups operating from Afghan territory.

Pakistan says leaders and fighters of the Tehreek-e-Taliban Pakistan are based in Afghanistan and have intensified attacks inside Pakistan. It also accuses Afghan territory of being used by Baloch insurgents.

Violence linked to these groups has risen steadily since 2022, according to the Armed Conflict Location & Event Data, contributing to mounting pressure on Islamabad to act.

The Taliban deny providing safe haven to militants targeting Pakistan and counter that Islamabad harbours fighters linked to Islamic State, Pakistan rejects.

The latest strike follows weeks of intensifying clashes, including Pakistani air and ground operations targeting Taliban positions and infrastructure along the border. Officials said those actions came after attacks by Afghan forces on Pakistani border posts.

Pakistan’s defence minister has described the situation as amounting to an “open war,” reflecting the scale of the confrontation.Earlier attempts to stabilise the situation, including a ceasefire mediated by Turkey, Qatar and Saudi Arabia, have failed to hold.

Repeated border clashes, closures and disruptions to trade have further strained ties between the neighbours, signalling a breakdown in what was once a closely aligned relationship.

The attack marked the first Israeli strike to hit the heart of Beirut since hostilities between Israel and the Iran-backed Hezbollah group resumed last week, widening the regional confrontation linked to the broader U.S.-Israel war with Iran.Israel’s military said the strike targeted key commanders belonging to the Lebanon Corps of Iran’s elite Quds Force, a unit within the Islamic Revolutionary Guard Corps (IRGC), although it did not identify the individuals it believed were present at the site.“The commanders of the Quds Force’s Lebanon Corps operated to advance terror attacks against the state of Israel and its civilians, while operating simultaneously for the IRGC in Iran,” the Israeli military said in a statement.

Strike hits central Beirut building.The strike struck an apartment within the Ramada hotel complex located in central Beirut, an area that had not been targeted since fighting resumed between Israel and Hezbollah.The building was housing displaced civilians who had fled fighting in southern Lebanon and Beirut’s southern suburbs, areas that have experienced repeated Israeli air strikes during the past week.Following the attack, witnesses said people were seen leaving the hotel amid concerns that additional strikes could follow.There was no immediate confirmation from Lebanese authorities regarding the identities of those killed or whether the victims included the Iranian commanders Israel said it had targeted.

Israel said the operation was aimed at disrupting activities by Iran’s Quds Force in Lebanon. The Quds Force oversees Iran’s foreign military operations and maintains close ties with allied groups across the region, including Hezbollah.The Israeli military has intensified strikes against Iranian-linked targets as the regional conflict expands.Last week, Israel said it had killed Daoud Ali Zadeh, the commander of Iran’s Quds Force in Lebanon, during a strike in Tehran. Israel said he had been involved in coordinating military activities linked to Iranian operations in the region.Lebanon drawn deeper into conflictLebanon has increasingly been pulled into the escalating confrontation between Israel and Iran.The latest phase of hostilities intensified on Monday when Hezbollah fired rockets and drones into Israel, according to Israeli officials. Hezbollah is backed by Iran and has been one of Tehran’s key regional allies.Israel responded with a wave of strikes across southern and eastern Lebanon, as well as locations near Beirut.The fighting has raised concerns about a broader regional escalation as the U.S.-Israel campaign against Iranian targets continues and allied armed groups across the Middle East become increasingly involved.The strike in central Beirut underscores the expanding geographic scope of the conflict and the growing risk that urban centres beyond traditional front lines could become targets as the confrontation deepens.