Humanitarian groups said the conflict has forced them to reroute shipments through longer and more expensive pathways, with transport costs rising sharply due to increased fuel prices and insurance premiums.

The disruption has compounded existing financial strain following reductions in U.S. foreign aid.The World Food Programme said tens of thousands of metric tons of food are currently delayed in transit.

The International Rescue Committee reported that pharmaceuticals intended for Sudan are stranded in Dubai, while hundreds of boxes of therapeutic food meant for malnourished children in Somalia remain stuck in India.

The United Nations Population Fund said it has also delayed shipments of medical equipment to 16 countries, underscoring the scale of the disruption.The United Nations described the situation as the most significant supply chain shock since the COVID-19 pandemic, with costs increasing by up to 20% as shipments are rerouted and delayed.

Aid agencies are increasingly relying on a combination of land, air and sea transport to bypass affected routes. UNICEF said it has shifted vaccine deliveries to Iran via Turkiye by air and road, adding about 10 days to delivery times and increasing costs by roughly 20%.

Save the Children said it has altered supply routes to Sudan, including overland transport through Saudi Arabia and barge crossings of the Red Sea, increasing delivery times by about 10 days and costs by approximately 25%.

The delays risk disrupting supplies to more than 90 primary health care facilities in Sudan.The Doctors Without Borders said rising fuel prices in Somalia have increased transport and food costs, limiting access to care for populations already facing severe food insecurity.Aid groups warned that the impact on global hunger could worsen significantly.

The World Food Programme said that if the conflict continues through June, an additional 45 million people could face acute hunger, adding to nearly 320 million already affected worldwide.The disruption also threatens agricultural production, with around 30% of global fertilizer supplies passing through the Strait of Hormuz.

Countries such as Sudan and Kenya rely heavily on imports from the Gulf, raising concerns about planting seasons in regions including East Africa and South Asia.

The United Nations said it has established a task force to facilitate fertilizer trade, but aid agencies cautioned that without a ceasefire and increased funding, humanitarian operations may struggle to meet rising needs.

The United States said it remains a leading contributor to global humanitarian assistance and announced an additional $50 million in emergency aid to Lebanon, including support for the World Food Programme, as it works with international partners to address the growing crisis.

Foreign Minister Badr Abdelatty held separate calls with U.S. envoy Steve Witkoff and Iranian Foreign Minister Abbas Araghchi, the ministry said in a statement, focusing on proposals aimed at reducing hostilities across the region.

The discussions come amid intensified diplomatic engagement by regional actors seeking to contain the conflict, which has disrupted energy flows and heightened geopolitical risks.

Turkiye and Pakistan have also taken on intermediary roles, with Islamabad recently hosting talks on de-escalation measures and proposals to reopen the Strait of Hormuz, a critical artery for global oil and gas shipments.

Egypt’s outreach reflects growing concern among regional powers over the potential for further escalation and the economic impact of prolonged disruptions, particularly on energy markets and trade routes.

ElBaradei, who led the International Atomic Energy Agency from 1997 to 2009, made the appeal in a post on X, urging regional governments to act before the situation deteriorates further. “Do everything in your power before this madman turns the region into a ball of fire,” he wrote, referring to Trump’s recent threats against Tehran.

In a separate post, ElBaradei questioned whether international actors could halt the escalation, tagging the United Nations, the European Union, as well as Emmanuel Macron, and the foreign ministries of China and Russia.

Trump has warned that Iran must either reach an agreement with Washington or reopen the Strait of Hormuz, a critical global energy route that has been effectively blocked since the outbreak of war following U.S.-Israeli strikes on Tehran on February 28. In a post on Truth Social, Trump reiterated that Iran faces a 48-hour deadline or risk severe military consequences.

The remarks come amid intensifying hostilities in the region, with ongoing strikes and countermeasures raising concerns over broader instability and disruption to global energy supplies.

ElBaradei, an Egyptian diplomat and former vice president, led the IAEA during the early years of international scrutiny over Iran’s nuclear program. He and the agency were jointly awarded the Nobel Peace Prize in 2005 for efforts to promote the peaceful use of nuclear energy.

The rescued officer was the second member of a two-person crew aboard an F-15 aircraft that Iran said it had shot down using its air defense systems. U.S. officials did not provide operational details of the recovery mission, and the Pentagon did not immediately respond to requests for comment.

Trump confirmed the recovery in a post on his Truth Social platform, describing the operation as one of the most complex search-and-rescue efforts conducted by U.S. forces in hostile territory. He said the airman, a senior officer, had been injured but was in stable condition and under monitoring.

“This is the first time in military memory that two U.S. pilots have been rescued, separately, deep in enemy territory,” Trump wrote, adding that the operation was carried out without U.S. casualties.The first crew member had already been recovered earlier, according to a Reuters report on Friday.

The aircraft was brought down amid ongoing hostilities between U.S. and Iranian forces following the outbreak of war on February 28.The developments come as Washington escalates its demands on Tehran to reopen the Strait of Hormuz, a critical global energy corridor that typically handles around 20% of the world’s oil and liquefied natural gas shipments.

Iran’s effective closure of the waterway has contributed to a growing energy crisis and heightened volatility in global markets.Trump reiterated that Iran faces a narrowing window to comply, stating that less than 48 hours remained before potential U.S. action.

His recent messaging has alternated between references to possible diplomatic progress and explicit threats of large-scale military strikes, including against Iran’s power infrastructure.The conflict has already resulted in thousands of deaths and significant disruption across the region, with mounting concerns over long-term economic damage and supply chain instability linked to restricted energy flows through the Gulf.

Iran has not publicly commented on the rescue operation but has previously stated that it deployed newly developed air defense systems in targeting U.S. aircraft operating in its airspace.

Sharif reiterated Pakistan’s support for Saudi Arabia’s security and sovereignty in the face of what he described as repeated Iranian attacks, according to the Saudi Press Agency.

The two leaders reviewed recent regional developments and the broader implications of the conflict for global stability.

The call came as Sharif indicated Pakistan could host talks aimed at ending the conflict, positioning Islamabad as a potential intermediary amid intensifying hostilities. In a statement on X, he said Pakistan supported efforts to pursue dialogue and a peaceful resolution.

The outreach follows remarks by U.S. President Donald Trump that Washington had engaged in “productive” discussions with Iran, a claim denied by Iranian military officials.Despite diplomatic signals, fighting has continued, with U.S., Israeli and Iranian strikes ongoing across the region.

Sources have indicated that Washington is preparing to deploy additional forces, including thousands of troops from the 82nd Airborne Division, adding to an existing U.S. presence of about 50,000 personnel in the Middle East.

The planned deployment underscores a broader military buildup that has raised concerns about a prolonged conflict even as parallel diplomatic efforts gain traction.

Pakistan’s potential role as a host for negotiations reflects its longstanding ties with Iran and its recent engagement with the United States, allowing it to project itself as a relatively neutral actor in the crisis.

The discussions between Riyadh and Islamabad come amid growing international efforts to contain the conflict’s geopolitical and economic fallout.

Speaking at UN headquarters, Guterres said the conflict had exceeded even worst-case expectations, warning of a potential global catastrophe if fighting continues.

He reiterated that diplomacy and adherence to international law remain the only viable path to de-escalation.

Guterres urged Tehran to stop strikes against regional states, noting that the United Nations Security Council has already condemned such actions and demanded their cessation. He also stressed the importance of safeguarding navigation rights in critical waterways, including the Strait of Hormuz.

He called on Washington and Israel to bring the war to an end, citing rising civilian casualties and intensifying humanitarian and economic consequences. “This has gone too far,” he said, warning against further escalation.

The UN chief said the prolonged disruption of maritime routes, particularly through the Strait of Hormuz, is constraining the flow of oil, gas and fertilizers at a crucial time for global agriculture, amplifying economic shocks and threatening food security.

He warned that the conflict’s repercussions are disproportionately affecting vulnerable populations, with humanitarian operations under increasing strain as violence spreads across multiple fronts.

Referring to his recent visit to Lebanon, Guterres cautioned against further deterioration there, calling on Hezbollah to halt attacks into Israel and urging Israel to stop strikes in Lebanese territory.

He warned that the humanitarian crisis seen in Gaza must not be repeated in Lebanon.Guterres said he remains engaged with regional and international stakeholders and announced the appointment of Jean Arnault as his personal envoy to coordinate diplomatic efforts related to the conflict and its broader consequences.

He emphasized that ending the war remains the most effective way to mitigate global disruption, reiterating that “peace is the way out.”