Officials said the virus likely circulated undetected for weeks because initial testing focused on more common Ebola strains. No approved vaccine currently exists for the Bundibugyo variant, with WHO estimating any targeted vaccine could take six to nine months to develop.

The outbreak is unfolding in conflict-hit areas of eastern Congo, where insecurity, population displacement and weak health infrastructure are complicating containment efforts.

The US State Department elevated the three countries to its highest advisory level, “Level 4: Do Not Travel,” while also advising citizens to reconsider travel to neighboring Rwanda due to its proximity to affected regions.

The advisory followed new emergency measures announced by the Centers for Disease Control and Prevention, including enhanced airport screening procedures for travelers arriving from outbreak-hit areas and temporary visa-related restrictions.

US health authorities said non-American passport holders who had traveled to Uganda, the Democratic Republic of Congo or South Sudan within the previous 21 days would face restrictions on entry into the United States.

The CDC said the risk of Ebola spreading within the United States remained low but confirmed it was coordinating the evacuation of an American doctor infected with the virus in the DRC, along with six additional individuals undergoing medical monitoring.
German authorities said on Tuesday they were prepared to receive the infected US doctor for treatment.

The latest outbreak involves a strain of Ebola for which no approved vaccine or treatment has yet proven effective, according to health officials.

The CDC said it was expanding technical support for authorities in the Democratic Republic of Congo and working with international partners to strengthen surveillance and containment operations.

The US State Department said Washington was mobilizing approximately $13 million in emergency assistance to support the response.

Questions have also emerged regarding whether recent funding cuts to the United States Agency for International Development affected outbreak preparedness and monitoring capabilities in the region. US officials declined to directly address concerns about whether reductions in USAID resources had weakened health response infrastructure.

US President Donald Trump said he was concerned about the outbreak but described the situation as currently confined to Africa.

Ebola, a highly infectious hemorrhagic fever first identified in 1976, has killed an estimated 15,000 people globally over the past five decades. Depending on the strain, fatality rates can reach as high as 90 percent.

Public health experts have long warned that fragile healthcare systems, regional instability and population displacement in parts of Central Africa complicate efforts to rapidly contain outbreaks.

The WHO said the outbreak did not yet meet the threshold for a pandemic emergency but warned that countries bordering Congo faced a heightened risk of further spread as infections expanded across eastern regions and new cases emerged in Uganda’s capital, Kampala.

According to the agency, 80 suspected deaths, eight laboratory-confirmed cases and 246 suspected infections had been reported as of Saturday in Congo’s Ituri province, particularly in the health zones of Bunia, Rwampara and Mongbwalu.

The Congolese health ministry had earlier confirmed that at least 80 people had died in the outbreak, which health officials believe may be significantly larger than currently documented because of high positivity rates in early testing and increasing numbers of suspected infections.

The outbreak involves the Bundibugyo strain of Ebola virus disease, a rarer variant for which no approved vaccines or targeted therapeutics currently exist, unlike the more common Ebola-Zaire strain that has been the focus of previous immunization campaigns in Central Africa.

The WHO described the situation as “extraordinary,” warning that international transmission had already been documented.

In Kampala, two unrelated laboratory-confirmed Ebola cases, including one death, were identified on Friday and Saturday in travelers arriving from Congo, according to the agency. A confirmed case was also detected in Kinshasa involving a traveler returning from Ituri province.

The WHO urged governments to activate national emergency-response systems, intensify border screening and strengthen surveillance along internal transportation routes to contain further spread.
The agency also advised that confirmed Ebola patients and close contacts should avoid international travel except for medical evacuation purposes.

It recommended immediate isolation of confirmed cases, daily monitoring of contacts and restrictions on domestic travel for exposed individuals until 21 days after potential infection.

At the same time, the WHO cautioned governments against shutting borders or imposing sweeping trade restrictions, warning that such measures could push movement across unofficial crossings beyond the reach of health monitoring systems.

The outbreak poses an additional challenge for regional health systems already strained by conflict, population displacement and limited medical infrastructure in eastern Congo, where previous Ebola epidemics have repeatedly tested emergency response capacities.

The assault occurred in Bafwakoa village in Mambasa territory of Ituri province, near the town of Niania, beginning around 7 p.m. local time, according to army statements and local authorities.

The Congolese military said the attackers were members of the Allied Democratic Forces (ADF), an armed group active in eastern Congo that has been recognized by Islamic State as an affiliate.

Local official Christian Alimasi said the attackers burned at least 44 houses, killed residents using machetes and fire, and abducted two people during the raid.

Violence linked to the ADF has intensified in recent months in Ituri and neighboring North Kivu province, despite joint military operations launched in 2021 by Congolese and Ugandan forces to counter the group.

Data from Insecurity Insight shows the ADF accounted for roughly a quarter of reported violence against civilians in eastern Congo between 2020 and 2025, underscoring the persistent security challenges in the region.